# Custom Panel

| Abbreviation | Definition                                                |
| ------------ | --------------------------------------------------------- |
| NGS          | next-generation sequencing                                |
| pangolin     | phylogenetic assignment of named global outbreak lineages |

| Category      | Test information                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      |
| ------------- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |
| RUO           | For Research Use Only. Not for use in diagnostic procedures.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |
| URL           | See <https://www.illumina.com/> for additional information.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| Pango lineage | The most likely Pango (phylogenetic assignment of named global outbreak) lineage is assigned to the majority consensus SARS-CoV-2 genome sequence using pangolin 4.3.1 (Áine O'Toole & Emily Scher et al. 2021 Virus Evolution DOI:10.1093/ve/veab064).                                                                                                                                                                                                                                                                                                                                                                               |
| Limitations   | Custom panel data analysis using DRAGEN Microbial Enrichment Plus aligns human-dehosted next-generation sequencing (NGS) reads to reference sequences. Contamination with microorganisms is possible during specimen collection, transport, and processing. Reads from closely related microorganisms may align to reference sequences based on sequence homology. Alignment of reads to a microorganism does not confirm that the microorganism is causing symptoms, is viable, or is infectious. Results should be interpreted in the context of all available information. Other sources of data may be required for confirmation. |